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KMID : 0043320040270121189
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Archives of Pharmacal Research
2004 Volume.27 No. 12 p.1189 ~ p.1193
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Total Synthesis of Norneolignans from Krameria Species
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Seo Pil-Ja
Choi Hong-Dae
Son Byeng-Wha
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Abstract
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The total synthesis of norneolignans isolated from Krameria species, 2-aryl-5-(E)-propenylbenzofurans (5, 11), is described. The key step involves the one-pot reaction for 2-arylbenzofurans (2, 7) from 4-hydroxyphenylacetone with 4’-acetoxy-2-chloro-2-(methylthio)acetophenone (1) and 2-chloro-2-methylthio-(2’,4’,6’-trimethoxy)acetophenone (6) under Friedel-Crafts reactionconditions.
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KEYWORD
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Norneolignans, Krameria species, 2-ARYL-5-(E)-propenylbenzofurans, 4-Hydroxyphenylacetone, 4’-Acetoxy-2-chloro-2-(methlthio)acetophenone, 2-Chloro-2-methylthio-(2’, 4’, 6’-trimethoxy)acetophenone, FRiedel-Crafts reaction
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